Albumin-Binding Domain (ABD)
Reported by Gemini Smith | March 26th, 2024 @ 06:50 PM
A strategy utilizing fusion with an albumin-binding domain-based half-life extension has been investigated which is aimed at increasing pharmacokinetics.
Many surface proteins produced by gram-positive bacteria have a tiny, three-helical protein domain known as the naturally occurring ABD with human serum albumin (HSA) binding property. The three homologous HSA-binding domains with comparable sequences are called ABD1, ABD2, and ABD3. ABDs have been investigated in great detail as half-life extension modules, and a number of derivatives with different albumin affinities have been created. For instance, adding recombinant antibody fragments to an ABD can greatly increase the half-life.
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Gemini Smith