The Beneficial Role of IgE in Host Defense
Reported by Gemini Smith | March 26th, 2024 @ 06:59 PM
The Direct Defense of
IgE Against Bee Venom
It has long been known that IgE plays a crucial role in allergy
symptoms such hives, swelling, wheezing, and in extreme situations,
anaphylactic shock. But this was the first time that IgEs were
shown to have a direct protective function against poisons. The
mice exhibited remarkable resistance to higher concentrations of
the toxin, the researchers discovered, after being exposed to
minute doses of bee venom. It is possible to compare the immune
response triggered by vaccination to this defensive immunological
response against the venom. However, the reaction in humans is very
different: in those who are sensitive, repeated exposure to bee
venom can result in severe allergic reactions. IgE is the main
actor in these kinds of reactions.
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