#91 new
Gemini Smith

New Class of Ribosomal Peptide

Reported by Gemini Smith | February 26th, 2024 @ 09:05 PM

A broad class of naturally occurring products known as ribosomally synthesized and post-translationally modified peptides (RiPPs) are produced by ribosomes and undergo post-translational modification. These peptides have a broad spectrum of structural and biological functions and are involved in numerous biological processes, such as immune response, cell signaling, and antimicrobial defense. "Genome mining unveils a class of ribosomal peptides with two amino termini​" is the title of a research study written by a group of researchers from the University of Illinois at Urbana-Champaign and published in the journal Nature Communications. The group describes a class of RiPPs known as "daptides" because of their peculiar (S)-N2,N2-dimethyl-1,2-propanediamine (Dmp)-modified C-terminus. Daptides possess two positively charged termini, which provides them a unique biological activity in contrast to other peptides that have one positively and one negatively charged terminus, or "end".

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