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Exosomes generated and secreted by malignant cells are known as tumor cell-derived exosomes. They are widely distributed in cancer patients' bodily fluids. Crucially, extracellular vesicles formed from normal cells cannot be confused with TEX because they carry distinct genetic and chemical cargos. Since TEX may travel freely through many organs, just like other EVs, it can be thought of as a means of communication between tumor and normal cells, including immune cells. When TEX with a payload of several molecular species, including nucleic acids, comes into touch with certain destination cells, it delivers its content and alters the activities of the recipient cells. Furthermore, research has shown that TEX can inhibit immune cell functions directly by supplying active lymphocytes with suppressive signals or chemicals, or indirectly by encouraging lymphocyte proliferation and activity.