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A set of proteins known as the complement system, when triggered, lyse target cells and facilitate phagocytosis by means of opsonization. Although it is possible to quantify individual complement components, this does not reveal anything about the functioning of this pathway. A screening test for the activation of the classical complement pathway is total complement activity/CH 50, sometimes referred to as CH 100. It is susceptible to any route component being reduced, removed, or rendered inactive. In order to more accurately ascertain the occurrence, severity, and response to treatment, the total complement CH50/CH100 assay can thoroughly comprehend the complement system's activation status. As a result, the complement activity test is clinically significant for both illness diagnosis and treatment.